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Mon, 27 Jul 2015 18:02:29 EDT
Clinical validation for LOXO-101 against TRK fusion cancer
The first imaging studies of TRK fusion cancer conducted post-treatment have confirmed that stage IV patient's tumors had substantially regressed. With four months of treatment, additional CT scans have demonstrated almost complete disappearance of the largest tumors.
Mon, 27 Jul 2015 18:02:22 EDT
Experimental drug treatment for Rett syndrome suggests disorder is reversible, mouse study shows
A strikingly new approach for treating Rett syndrome has been developed by scientists, a devastating autism spectrum disorder. In their report, the researchers demonstrate that treatment with small-molecule drug candidates significantly extends lifespan in male mice that model Rett and ameliorates several behavioral symptoms in females.
Mon, 27 Jul 2015 18:02:20 EDT
Flow means 'go' for proper lymph system development
The lymph system provides a slow flow of fluid from tissues into the blood. It returns fluid and proteins that leak from blood vessels, provides passage for immune cells from the tissues to the blood, and hosts key niches for immune cells. How this system develops hasn't been well understood, but now researchers have found from that the early flow of lymph fluid is a critical factor in the development of mature lymphatic vessels.
Mon, 27 Jul 2015 15:38:12 EDT
One in four patients with defibrillators experiences boost in heart function over time
A study of outcomes among 1,200 people with implanted defibrillators — devices intended to prevent sudden cardiac death from abnormal heart rhythms — shows that within a few years of implantation, one in four experienced improvements in heart function substantial enough to put them over the clinical threshold that qualified them to get a defibrillator in the first place. A report on the study reveals these patients had markedly lower risk of dying and were far less likely to suffer arrhythmia-terminating device shocks, suggesting their hearts had grown less prone to developing lethal rhythms.
Mon, 27 Jul 2015 15:37:35 EDT
Mobile stroke treatment units may greatly improve survival rates, chance of recovery for ischemic stroke patients
Mobile Stroke Treatment Units (MSTUs) can significantly reduce the time it takes to diagnose and treat patients for stroke, new research confirms. MSTUs resemble ambulances on the outside, but contain highly specialized staff, equipment and medications strictly used for diagnosing and treating strokes. Specifically, they are equipped with diagnostic tools and telemedicine capabilities that facilitate real-time communication with hospital-based stroke specialists, enabling immediate diagnosis and the administration of IV tPA for eligible patients while en route to the hospital.
Mon, 27 Jul 2015 15:37:31 EDT
Narrowing in on pituitary tumors
A new technique that could help surgeons more precisely define the locations of pituitary tumors in near real-time has been demonstrated by a team of scientists. The new strategy uses a visualization technique (matrix-assisted laser desorption/ionization mass spectrometry imaging -- MALDI MSI) that can analyze specific hormones, including growth hormone and prolactin, in tissue.
Mon, 27 Jul 2015 15:37:29 EDT
Gene therapy may improve survival of patients with recurrent ovarian cancer
Use of gene therapy to deliver a protein that suppresses the development of female reproductive organs may improve the survival of patients with ovarian cancer that has recurred after chemotherapy, which happens 70 percent of the time and is invariably fatal.
Mon, 27 Jul 2015 15:37:27 EDT
In CRISPR advance, scientists successfully edit human T cells
Scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9. Because these immune-system cells play important roles in a wide range of diseases, from diabetes to AIDS to cancer, the achievement provides a versatile new tool for research on T cell function, as well as a path toward CRISPR/Cas9-based therapies for many serious health problems.
Mon, 27 Jul 2015 15:04:38 EDT
Blood markers identify women at risk for postpartum depression
The hormone oxytocin, sometimes called 'the love hormone,' may be a factor in postpartum depression, when a mother has a lower than normal level. A blood marker now may help identify the risk, investigators now report.
Mon, 27 Jul 2015 15:04:35 EDT
Some stroke treatments proven to reduce health care costs
Use of mechanical thrombectomy on qualifying stroke patients could result in major savings to the healthcare economy in the United Kingdom and other western countries with a similar healthcare structure, according to a new study.
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