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Molecular Biology News
Wed, 30 Jul 2014 17:31:30 EDT
Mechanism promoting multiple DNA mutations described by scientists
Recent studies have shown that cancer development frequently involves the formation of multiple mutations that arise simultaneously and in close proximity to each other. These groups of clustered mutations are frequently found in regions where chromosomal rearrangements take place. The finding that cancer development often involves multiple mutations arising in clusters and in regions where chromosomal rearrangement takes place may one day lead to new cancer therapies.
Tue, 29 Jul 2014 15:29:23 EDT
Vaccine against tick-transmitted disease under development
An important advancement toward developing a vaccine against the debilitating and potentially deadly tick-transmitted disease, human granulocytic anaplasmosis has been made by scientists. Successful vaccine development hinges on knowing what to target to prevent disease, and the research team has identified three such proteins on the surface of the HGA agent.
Tue, 29 Jul 2014 09:31:16 EDT
New method provides researchers with efficient tool for tagging proteins
With a new method, researchers use a piece of DNA engineered to bind to metal ions. Using this 'control stick,' they direct another piece of DNA to a metal binding site on the protein. The new method makes it possible to direct the tagging of proteins with DNA to a particular site on the protein, without genetically modifying the protein beforehand. In other words, it is possible to tag natural proteins, including antibodies.
Tue, 29 Jul 2014 08:45:39 EDT
Microscopic rowing -- without a cox: Cells' whip-like appendages can synchronize their movements
New research shows that the whip-like appendages on many types of cells are able to synchronize their movements solely through interactions with the fluid that surrounds them.
Tue, 29 Jul 2014 07:35:24 EDT
Healthy lifestyle may buffer against stress-related cell aging
A new study shows that while the impact of life’s stressors accumulate overtime and accelerate cellular aging, these negative effects may be reduced by maintaining a healthy diet, exercising and sleeping well.
Mon, 28 Jul 2014 16:23:46 EDT
Forced mutations doom HIV: How potential HIV drug exacts its toll on viral populations
Fifteen years ago, medical researchers had a novel idea for an HIV drug. They thought if they could induce the virus to mutate uncontrollably, they could force it to weaken and eventually die out -- a strategy that our immune system uses against many viruses.
Mon, 28 Jul 2014 15:40:32 EDT
Stress-tolerant tomato relative sequenced
The genome of Solanum pennellii, a wild relative of the domestic tomato, has been published by an international group of researchers. The new genome information may help breeders produce tastier, more stress-tolerant tomatoes.
Mon, 28 Jul 2014 15:39:41 EDT
Cell's recycling center implicated in division decisions
Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers have now identified a mechanism that overrides the cells' warning signals, enabling cancers to continue to divide even without a robust blood supply. In the process, the researchers found that lysosomes -- the cell's protein 'recycling centers' -- help govern cell division decisions.
Mon, 28 Jul 2014 15:36:38 EDT
Researchers produce record-length mirror-image protein
Biochemists have reported an advance in the production of functional mirror-image proteins. In a new study, they have chemically synthesized a record-length mirror-image protein and used this protein to demonstrate that a cellular chaperone, which helps "fold" large or complex proteins into their functional state, has a previously unappreciated talent -- the ability to fold mirror-image proteins. These findings will greatly facilitate mirror-image protein production for applications in drug discovery and synthetic biology.
Mon, 28 Jul 2014 12:37:29 EDT
The role of dairy in maintaining adult bone and skeletal muscle health
Understanding that diets are often built around food groups rather than specific nutrients, researchers from Switzerland, France, and North America decided to examine interactions between four nutrients found in dairy products and their role in preserving bone and skeletal muscle.
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