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Molecular Biology News
Sat, 21 May 2016 07:14:12 EDT
Neutrons probe structure of enzyme critical to development of next-generation HIV drugs
Medical researchers used neutron analysis to better understand a protein implicated in the replication of HIV, the retrovirus that causes AIDS. The enzyme, known as HIV-1 protease, is a key drug target for HIV and AIDS therapies. The multi-institutional team used neutron crystallography to uncover detailed interactions of hydrogen bonds at the enzyme’s active site, revealing a pH-induced proton ‘hopping’ mechanism that guides its activity.
Sat, 21 May 2016 07:12:03 EDT
Chemists settle longstanding debate on how methane is made biologically
Like the poet, microbes that make methane are taking chemists on a road less traveled: Of two competing ideas for how microbes make the main component of natural gas, the winning chemical reaction involves a molecule less favored by previous research, something called a methyl radical. Reported today the work is important for understanding not only how methane is made, but also how to make things from it.
Fri, 20 May 2016 11:06:38 EDT
Liquid order: Fluid self-organizes into structure that controls cell growth, health
Although known since the 1830s as a round, dark spot in a cell's nucleus, only recently has the nucleolus gotten its full due. Scientists have now discovered how the nucleolus, an organelle with the consistency of honey, maintains a complex internal structure.
Fri, 20 May 2016 11:06:34 EDT
Researchers solve the structure of the Zika virus helicase
Scientists have solved the structure of the Zika virus helicase, which is a key target for antiviral development.
Fri, 20 May 2016 10:19:57 EDT
First signalling pathway of the digestive lineage in planarians better understood
A scientific study describes for the first time the function of a signalling pathway –particularly, the pathway of epidermal growth factor receptors (EGFR) - in the differentiation of the planarian digestive lineage. EGFR pathway, evolutionarily preserved, has a fundamental role when regulating the cell differentiation and proliferation in lots of organisms (such as mammals’ neural stem cells) and it is over-activated in most of human cancers.
Fri, 20 May 2016 10:10:25 EDT
Enzyme pair play crucial role in maintaining balance of cellular processes
Scientists show that ULK1 and ULK2, two enzymes involved in autophagy, regulate the trafficking of proteins between select cellular compartments, a new report outlines.
Thu, 19 May 2016 14:45:29 EDT
Factor preserves DNA integrity in bacteria despite assault from antibiotics
A key biochemical enables bacteria to repair otherwise fatal damage to their DNA, including that caused by antibiotics, report scientists. The study results revolve around the delicacy of DNA molecules, the letters making up the genetic code. Experts estimate that DNA is damaged thousands of times an hour in each bacterial cell, and perhaps a million times a day in a human cell with larger, more complicated DNA chains. Sunlight and toxins do much of the damage, but the biggest culprit may be highly reactive byproducts created as cells use oxygen to turn sugar into energy.
Thu, 19 May 2016 14:08:28 EDT
A path away from reliance on oil, with the help of bacteria
Adding genes to bacteria offers sustainable routes to make compounds currently obtained from petrochemicals.
Thu, 19 May 2016 13:02:46 EDT
Plant cell wall development revealed in space and time for the first time
Scientists have mapped changes in composition of plant cell walls over space and time, providing new insights into the development and growth of all plants. The cell wall is a defining feature of plant cells, providing essential functions like strength and mechanical support to plant tissues.
Thu, 19 May 2016 13:02:40 EDT
Study identifies unexpected mutation in commonly used research mice
A strain of inbred mice commonly used for the creation of so-called knockout animals has been found to carry a previously undetected mutation that could affect the results of immune system research studies.
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