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Molecular Biology News
Mon, 19 Feb 2018 10:32:56 EST
How the insulin receptor works
As we are approaching the 100th anniversary of the discovery of insulin, a wide array of its signaling pathways has been defined. However, the initial step in insulin action, i.e. the engagement with its cell-surface receptor and the resulting conformational change, which propagates across the plasma membrane to the intracellular module, remains poorly understood.
Mon, 19 Feb 2018 10:24:13 EST
An enzyme's evolution from changing electric fields and resisting antibiotics
Bacteria can produce enzymes that make them resistant to antibiotics; one example is the TEM beta-lactamase enzyme, which enables bacteria to develop a resistance to beta-lactam antibiotics, such as penicillin and cephalosporins. Researchers are now studying how an enzyme changes and becomes antibiotic-resistant.
Sun, 18 Feb 2018 13:59:07 EST
Studying mitosis' structure to understand the inside of cancer cells
Cell division is an intricately choreographed ballet of proteins and molecules that divide the cell. During mitosis, microtubule-organizing centers assemble the spindle fibers that separate the copying chromosomes of DNA. While scientists are familiar with MTOCs' existence and the role they play in cell division, their actual physical structure remains poorly understood. Researchers are now trying to decipher their molecular architecture.
Sun, 18 Feb 2018 13:59:04 EST
What makes circadian clocks tick?
Circadian clocks arose as an adaptation to dramatic swings in daylight hours and temperature caused by the Earth's rotation, but we still don't fully understand how they work. Scientists studying the circadian clock of blue-green colored cyanobacteria. The group discovered that how the proteins move hour by hour is central to cyanobacteria's circadian clock function.
Sun, 18 Feb 2018 13:59:01 EST
Ras protein's role in spreading cancer
Protein systems make up the complex signaling pathways that control whether a cell divides or, in some cases, metastasizes. Ras proteins have long been the focus of cancer research because of their role as 'on/off switch' signaling pathways that control cell division and failure to die like healthy cells do. Now, a team of researchers has been able to study precisely how Ras proteins interact with cell membrane surfaces.
Sun, 18 Feb 2018 13:58:58 EST
Using mutant bacteria to study how changes in membrane proteins affect cell functions
Fri, 16 Feb 2018 15:03:38 EST
Cells communicate in a dynamic code
Scientists discover an unexpectedly dynamic vocabulary for the language of cellular communication.
Thu, 15 Feb 2018 14:17:27 EST
Plant survival under high salinity: Plant cell wall sensing mechanism
How cells sense their physical state and compensate for cell wall damage is poorly understood. But a new analysis of plants exposed to salt stress offers the first experimental evidence and molecular mechanisms showing how FERONIA is essential for the cellular responses that ensure survival under high salinity.
Thu, 15 Feb 2018 14:17:24 EST
New CRISPR-Cas9 tool edits both RNA and DNA precisely, U-M team reports
A tool that has already revolutionized disease research may soon get even better, thanks to an accidental discovery in the bacteria that cause many of the worst cases of meningitis.
Thu, 15 Feb 2018 14:17:19 EST
Birds and primates share brain cell types linked to intelligence
In a new study scientists show that some neurons in bird brains form the same kind of circuitry and have the same molecular signature as cells that enable connectivity between different areas of the mammalian neocortex. The researchers found that alligators share these cell types as well, suggesting that while mammal, bird and reptile brains have very different anatomical structures, they operate using the same shared set of brain cell types.
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