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14-3-3 Induced Apoptosis

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Description

Apoptosis is a physiological process of cell death that plays a critical role in normal development as well as in the pathophysiology of a variety of diseases. The fundamental cellular mechanism behind apoptosis is due to a balance between anti-apoptotic and pro-apoptotic factors, which may be shifted by extracellular signals. 14-3-3 proteins play an important suppressing role in several apoptotic pathways in animals. These are a family of abundant, widely expressed 28-33-kDa acidic polypeptides that spontaneously self-assemble as dimmers. The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. There are at least seven distinct genes for 14-3-3 in vertebrates, giving rise to nine isotypes (Alpha, Beta, Gamma, Delta, Epsilon, Eta, Sigma, Tau, and Zeta, with Alpha [...]

References:

1.14-3-3 proteins--an update.
Mhawech P.
Cell Res. 2005 Apr;15(4):228-36.
2.Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins.
Halbach T, Scheer N, Werr W.
Nucleic Acids Res. 2000 Sep 15; 28(18): 3542-50.
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