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14-3-3 Induced Intracellular Signaling

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The 14-3-3 proteins are a family of conserved adaptor and scaffolding proteins expressed in all eukaryotic cells. It has evolved from a brain-specific protein to a family of ubiquitously expressed regulatory molecules of eukaryotic organisms. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally wide array of cellular proteins, including kinases, phosphatases, and transmembrane receptors. This plethora of interacting proteins allows 14-3-3 to play important roles in a wide range of vital regulatory processes, such as neuronal development, mitogenic signal transduction, apoptotic cell death, cell cycle control, cell growth control, and viral and bacterial pathogenesis. More than 50 signaling proteins have been reported as 14-3-3 ligands (Ref.1).

There are seven known mammalian 14-3-3 isoforms, [...]


1.Role of 14-3-3 proteins in eukaryotic signaling and development.
Darling DL, Yingling J, Wynshaw-Boris A.
Curr Top Dev Biol. 2005;68:281-315.
2.14-3-3 proteins: a number of functions for a numbered protein.
Bridges D, Moorhead GB.
Sci STKE. 2005 Aug 9;2005(296):re10.
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