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Description |
The 14-3-3 proteins are a family of highly conserved proteins that play important roles in a wide range of cellular processes including signal transduction, apoptosis, cell cycle progression, and checkpoint activation within all eukaryotic cells. These 28–33 kDa helical molecules include nine isotypes (Alpha, Beta, Gamma, Delta, Epsilon, Eta, Sigma, Tau, and Zeta, with Alpha and Delta being phosphorylated forms of Beta and Zeta, respectively) in mammals and 2 to 12 proteins in yeast, fungi, and plants. 14-3-3 proteins form homo- and heterodimeric U-shaped structures that bind to a large number of phosphorylated signaling molecules through the large central channel in the center of the U (Ref.1).
14-3-3 proteins regulate the cell cycle and prevent apoptosis by controlling the nuclear and [...] |
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References:
1. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MBJ Cell Biol. 2002 Mar 4; 156(5): 817-28. Epub 2002 Feb 25. Erratum in: J Cell Biol 2002 Apr 29; 157(3): 533.2. Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.Bulavin DV, Higashimoto Y, Demidenko ZN, Meek S, Graves P, Phillips C, Zhao H, Moody SA, Appella E, Piwnica-Worms H, Fornace AJ Jr.Nat Cell Biol. 2003 Jun; 5(6): 545-51.
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