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14-3-3 and Cell Cycle Regulation

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Description

14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. While lower eukaryotes, e.g. yeast, contain only two 14-3-3 genes, higher eukaryotes possess up to 15 14-3-3 genes. For example, in mammals seven isoforms (beta, epsilom, eta, gamma, tau, zeta and sigma) have been identified to date. 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. The role of 14-3-3 proteins during cell cycle progression include regulating the onset and timing of mitosis in cycling cells, maintaining a stable G1-arrest in non-cycling cells and necessary for the S-phase checkpoint after DNA-damage by UV-B [...]

References:

1.14-3-3 proteins: a family of versatile molecular regulators
Obsilová V, Silhan J, Boura E, Teisinger J, Obsil T.
Physiol Res. 2008;57 Suppl 3:S11-21. Epub 2008 May 13. Review.
2.14-3-3 proteins in cell cycle regulation.
Hermeking H, Benzinger A.
Semin Cancer Biol. 2006 Jun;16(3):183-92. Epub 2006 Apr 1. Review.
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