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14-3-3 and Cell Cycle Regulation

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Co-ordinated progression through the cell cycle is essential for the maintenance of genomic integrity. 14-3-3 proteins play particularly important roles in coordinating progression of cells through the cell cycle, regulating their response to DNA damage, and influencing life-death decisions following internal injury or external cytokine-mediated cues. 14-3-3 proteins function at several key points in G1/S- and G2/M-transition by binding to regulatory proteins and modulating their function. The association with 14-3-3 proteins requires a specific phosphorylation of the protein ligand and mediates cell cycle arrest. 14-3-3 binding may lead to cytoplasmic sequestration of the protein ligand but may also have other functional consequences (Ref.1 and 2).

14-3-3 proteins regulate the onset and timing of mitosis in cycling cells, play a critical role [...]


1.14-3-3 proteins as signaling integration points for cell cycle control and apoptosis.
Gardino AK, Yaffe MB.
Semin Cell Dev Biol. 2011 Sep;22(7):688-95. doi: 10.1016/j.semcdb.2011.09.008. Epub 2011 Sep 14. Review.
2.14-3-3 proteins in cell cycle regulation.
Hermeking H, Benzinger A.
Semin Cancer Biol. 2006 Jun;16(3):183-92. Epub 2006 Apr 1. Review.
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