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Description |
Apoptosis plays a critical role in normal development as well as in the
pathophysiology of a variety of diseases, such as cancer. It is tightly
regulated, and a pivotal component of this regulation is the BCL2 (B-Cell
CLL/Lymphoma-2) family of pro- and antiapoptotic proteins. Its members include
pro-apoptotic proteins (e.g., BAD, BID, BAX, BAK, BCL-XS) as well as
anti-apoptotic proteins (e.g., BCL2, BCL-XL, Bfl-1/A1, MCL1) (Ref.1). 14-3-3
proteins are a family of conserved adaptor that interact with a pro-apoptotic
member of the BCL2 family, BAD
(BCL2 Associated Death Promoter), in a phosphoserine-dependent
manner and antagonizes the pro-apoptotic activity of BAD, providing a novel
signal integration point for control of cell death.
In contrast to SH2
(Src Homology-2) and PTB (Phospho-Tyrosine Binding) [...] |
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References:
1. 14-3-3 proteins in apoptosis.Rosenquist M.Braz J Med Biol Res. 2003 Apr; 36(4): 403-8. Epub 2003 Apr 08. Review.2. 14-3-3 proteins; bringing new definitions to scaffolding.Tzivion G, Shen YH, Zhu JOncogene. 2001 Oct 1; 20(44): 6331-8. Review.
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