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14-3-3 and Regulation of BAD Activity

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Description

Apoptosis plays a critical role in normal development as well as in the pathophysiology of a variety of diseases, such as cancer. It is tightly regulated, and a pivotal component of this regulation is the BCL2 (B-Cell CLL/Lymphoma-2) family of pro- and antiapoptotic proteins. Its members include pro-apoptotic proteins (e.g., BAD, BID, BAX, BAK, BCL-XS) as well as anti-apoptotic proteins (e.g., BCL2, BCL-XL, Bfl-1/A1, MCL1) (Ref.1). 14-3-3 proteins are a family of conserved adaptor that interact with a pro-apoptotic member of the BCL2 family, BAD (BCL2 Associated Death Promoter), in a phosphoserine-dependent manner and antagonizes the pro-apoptotic activity of BAD, providing a novel signal integration point for control of cell death.

In contrast to SH2 (Src Homology-2) and PTB (Phospho-Tyrosine Binding) [...]

References:

1.14-3-3 proteins in apoptosis.
Rosenquist M.
Braz J Med Biol Res. 2003 Apr; 36(4): 403-8. Epub 2003 Apr 08. Review.
2.14-3-3 proteins; bringing new definitions to scaffolding.
Tzivion G, Shen YH, Zhu J
Oncogene. 2001 Oct 1; 20(44): 6331-8. Review.
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