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14-3-3 and Regulation of BAD Activity

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14-3-3 is a phosphoserine/phosphothreonine-binding protein that is being implicated in a wide range of cellular phenomena. 14-3-3 family members are found in all eukaryotes – from plants to mammals – and more than 100 binding partners have been identified to date. They regulate their activities by a number of different mechanisms, which include inter- and intracompartmental sequestration, activation/inactivation of enzymatic activity and promotion/inhibition of protein interactions. The targets of 14-3-3 are found in all sub cellular compartments and their functional diversity is overwhelming – they include transcription factors, biosynthetic enzymes, cytoskeletal proteins, signaling molecules, apoptosis factors and tumor suppressors (Ref.1 & 2). 14-3-3 family of proteins consists of seven members (ζ, σ, β, η, θ, γ and ε) (Ref.3).

14-3-3 [...]


1.14-3-3 proteins as signaling integration points for cell cycle control and apoptosis.
Gardino AK, Yaffe MB.
Semin Cell Dev Biol. 2011 Sep;22(7):688-95. doi: 10.1016/j.semcdb.2011.09.008. Epub 2011 Sep 14. Review.
2.The 14-3-3 cancer connection.
Hermeking H.
Nat Rev Cancer. 2003 Dec;3(12):931-43. Review. No abstract available.
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