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ABC Transporters in Cholestatic Hepatocytes

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A cell must selectively translocate molecules across its plasma membrane to maintain the chemical composition of its cytoplasm distinct from that of the surrounding milieu. The most intriguing and, arguably, the most important membrane proteins for this purpose are the ABC (ATP-Binding Cassette) transporters. These proteins, found in all species, use the energy of ATP hydrolysis to translocate specific substrates across cellular membranes. The chemical nature of the substrates handled by ABC transporters is extremely diverse--from inorganic ions to sugars and large polypeptides--yet ABC transporters are highly conserved (Ref.1).

Transporters have been classified as primary, secondary, or tertiary active transporters. Secondary or tertiary active transporters, such as OAT (Organic Anion Transporter), OATP (Organic Anion-Transporting Polypeptides), NTCP (Na+-bile acid cotransporting protein), OCT1 [...]


1.Structure and mechanism of ABC transporters.
Wilkens S.
F1000Prime Rep. 2015 Feb 3;7:14. doi: 10.12703/P7-14. eCollection 2015. Review.
2.Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.
Telbisz Á, Homolya L.
Expert Opin Ther Targets. 2016;20(4):501-14. doi: 10.1517/14728222.2016.1102889. Epub 2015 Nov 17. Review.
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