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ABC Transporters in Cholestatic Hepatocytes

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Description

A cell must selectively translocate molecules across its plasma membrane to maintain the chemical composition of its cytoplasm distinct from that of the surrounding milieu. The most intriguing and, arguably, the most important membrane proteins for this purpose are the ABC (ATP-Binding Cassette) transporters. These proteins, found in all species, use the energy of ATP hydrolysis to translocate specific substrates across cellular membranes. The chemical nature of the substrates handled by ABC transporters is extremely diverse--from inorganic ions to sugars and large polypeptides--yet ABC transporters are highly conserved (Ref.1).

Transporters have been classified as primary, secondary, or tertiary active transporters. Secondary or tertiary active transporters, such as OAT (Organic Anion Transporter), OATP (Organic Anion-Transporting Polypeptides), NTCP (Na+-bile acid cotransporting protein), OCT-1 (Organic Cation Transporter), OCTN, and PEPT, are driven [...]

References:

1.From blood to bile: recent advances in hepatobiliary transport.
Arrese M, Accatino L.
Ann Hepatol. 2002 Apr-Jun; 1(2):64-71.
2.Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2.
Dietrich CG, Geier A, Salein N, Lammert F, Roeb E, Oude Elferink RP, Matern S, Gartung C.
Gastroenterology. 2004 Apr; 126(4):1044-53.
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