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AHR Pathway

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AHR (Aryl Hydrocarbon Receptor) is a member of the bHLH (basic Helix–Loop–Helix)- PAS (Per-ARNT-Sim) family of transcriptional regulators that control a variety of developmental and physiological events, including Neurogenesis, Tracheal and Salivary duct formation, Toxin metabolism, Circadian rhythms, response to Hypoxia and Hormone Receptor function. The unique feature of all bHLH-PAS proteins is the PAS domain, named after the first three proteins identified with this motif, the Drosophila Per, Human ARNT and Drosophila Sim. The PAS domain consists of 260–310 amino acids and incorporates two well-conserved hydrophobic repeats, termed PAS-A and PAS-B, separated by a poorly conserved spacer. Overall, the PAS domain is not well conserved and can mediate a number of diverse biochemical functions. AHR, also known as the [...]


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