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AIF Pathway

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Description

AIF (apoptosis-inducing factor), is a phylogenetically old flavoprotein which is confined to the mitochondrial intermembrane space in healthy cells but upon lethal signaling, it translocates, via the cytosol, to the nucleus where it binds to DNA and provokes Caspase-independent chromatin condensation [Ref.1]. Proteolysis of the membrane tether in mature AIF can be mediated by local or cytoplasmic proteases entering the intermembrane space upon permeabilization of the outer membrane. Mitochondrial membrane permeabilization leads to the release of other IMS (Intermembrane Space) proteins, such as CYCS (Cytochrome-C), SMAC (Second Mitochondria-Derived Activator of Caspase12)/DIABLO and ENDOG that take part in the apoptotic process. BCL2L1 (Bcl2 Related Protein Long Isoform), which blocks both AIF and CYCS releases from mitochondria [Ref.1&2].

The Detached AIF is [...]

References:

1.Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?
Candé C, Cecconi F, Dessen P, Kroemer G.
J Cell Sci. 2002 Dec 15; 115(Pt 24):4727-34.
2.Apoptosis-inducing factor: structure, function, and redox regulation.
Sevrioukova IF.
Antioxid Redox Signal. 2011 Jun 15; 14(12):2545-79. doi: 10.1089/ars.2010.3445. Epub 2011 Mar 10.
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