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AMPK Enzyme Complex Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


One of the key functions of catabolic metabolism is to maintain high levels of ATP (Adenosine Triphosphate) and cells rapidly respond to any stress that threatens to lower ATP levels by arresting non-essential ATP-utilizing functions and stimulating available ATP-generating pathways. A central player in this system is the AMPK (AMP (Adenosine 5 -Monophosphate)-Activated Protein Kinase). AMPK is a master metabolic regulator responsible for modulating cellular responses to an energy challenge. The evolutionarily conserved Serine/Threonine Kinase, AMPK acts as a “Fuel Gauge” or “Cellular Energy Sensor” and inhibits key enzymes of ATP-consuming pathways and induces pathways that generate ATP. When AMPK is activated by stimuli like muscle contraction, inflammation, sepsis, metabolic poisoning, exercise, hypoxia, ischemia, heat shock, neuronal necrosis, etc it controls [...]


1.AMPK: guardian of metabolism and mitochondrial homeostasis.
Herzig S, Shaw RJ.
Nat Rev Mol Cell Biol. 2017 Oct 4. doi: 10.1038/nrm.2017.95. [Epub ahead of print] Review.
2.The Warburg effect and drug resistance.
Bhattacharya B, Mohd Omar MF, Soong R.
Br J Pharmacol. 2016 Mar;173(6):970-9. doi: 10.1111/bph.13422. Epub 2016 Feb 18. Review.
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