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AMPK Enzyme Complex Pathway

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One of the key functions of catabolic metabolism is to maintain high levels of ATP (Adenosine Triphosphate) and cells rapidly respond to any stress that threatens to lower ATP levels by arresting non-essential ATP-utilizing functions and stimulating available ATP-generating pathways. A central player in this system is the AMPK (AMP (Adenosine 5 -Monophosphate)-Activated Protein Kinase). AMPK is a master metabolic regulator responsible for modulating cellular responses to an energy challenge. The evolutionarily conserved Serine/Threonine Kinase, AMPK acts as a “Fuel Gauge” or “Cellular Energy Sensor” and inhibits key enzymes of ATP-consuming pathways and induces pathways that generate ATP. When AMPK is activated by stimuli like muscle contraction, inflammation, sepsis, metabolic poisoning, exercise, hypoxia, ischemia, heat shock, neuronal necrosis, etc it controls many metabolic processes that include increased Glucose uptake; [...]


1.Management of cellular energy by the AMP-activated protein kinase system.
Hardie DG, Scott JW, Pan DA, Hudson ER.
FEBS. Lett. 2003 Jul 3;546(1):113-20.
2.Physiological and pathological responses to hypoxia.
Michiels C.
Am. J. Pathol. 2004 Jun;164(6):1875-82.
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