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APRIL Pathway

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APRIL (a proliferation-inducing ligand, also known as TRDL-1, TALL-2, and TNFSF13), is a member of the TNF (tumor necrosis factor) superfamily, with homologous structure and function to several other cytokines in this family. It is a cytokine which is over-expressed by transformed cells and could stimulate cellular proliferation (Ref.1) It has two receptors i.e BCMA and TACI (Tumor necrosis factor receptor superfamily members 17 and 13B) that play important roles in the B-cell and T-cell arms of the immune system (Ref.2 & 3). One of the most important APRIL-induced mechanism is an activation of NF-kB (Nuclear factors of kappa light polypeptide in B-cells) signaling cascades. Activation and nuclear translocation of NF-kB proteins can occur by one of two [...]


1.APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway.
1. Wang G, Wang F, Ding W, Wang J, Jing R, Li H, Wang X, Wang Y, Ju S, Wang H.
PLoS One. 2013; 8(1):e55298. doi: 10.1371/journal.pone.0055298. Epub 2013 Jan 29.
2.APRIL:TACI axis is dispensable for the immune response to rabies vaccination.
2. Haley SL, Tzvetkov EP, Lytle AG, Alugupalli KR, Plummer JR, McGettigan JP.
Antiviral Res. 2017 Aug;144:130-137. doi: 10.1016/j.antiviral.2017.06.004. Epub 2017 Jun 12.
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