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APRIL Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


The TNF (Tumor Necrosis Factor) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of approximately 50 membrane and soluble proteins that can modulate cellular function. Most of these molecules are expressed by or can target cells of the immune system, and they have a wide range of actions including promoting cellular differentiation, survival, and production of inflammatory cytokines and chemokines. Members of the TNFRSF (Tumor Necrosis Factor Receptor superfamily ) participate prominently in B-cell maturation and function. In particular, BAFFR (B-cell Activating Factor) belonging to the TNF family receptor, BCMA (B-Cell Maturation Antigen), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) play critical roles in promoting B-cell survival at distinct stages of development by engaging a proliferation-inducing [...]


1.Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease.
Rickert RC, Jellusova J, Miletic AV.
Immunol Rev. 2011 Nov;244(1):115-33. doi: 10.1111/j.1600-065X.2011.01067.x.
2.In vitro and in vivo activation induces BAFF and APRIL expression in B cells.
Chu VT, Enghard P, Riemekasten G, Berek C.
J Immunol. 2007 Nov 1;179(9):5947-57.
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