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Actin Nucleation and Branching

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The actin family is a diverse and evolutionarily ancient group of proteins that provide the supportive framework to the three-dimensional structure of eukaryotic cells. It provides the forces that enable the cell to adopt a variety of shapes and to undertake directed movements. Certain cell types, such as polymorphonuclear leukocytes, monocyte/macrophages, and metastatic cells, are able to move rapidly through tissues and these movements are mediated by the actin cytoskeleton (Ref.1). An important property of actin is its ability to produce movement in the absence of motor proteins. At the cell membrane actin microfilament assembly protrudes the membrane forward producing the ruffling membranes in actively moving cells. These microfilaments also play a passive structural role by providing the internal stiffening [...]


1.Origin and evolution of the self-organizing cytoskeleton in the network of eukaryotic organelles.
Jékely G.
Cold Spring Harb Perspect Biol. 2014 Sep 2;6(9):a016030. doi: 10.1101/cshperspect.a016030. Review.
2.Dynamic regulation of sarcomeric actin filaments in striated muscle.
Ono S.
Cytoskeleton (Hoboken). 2010 Nov;67(11):677-92. doi: 10.1002/cm.20476. Review.
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