ProteinLounge
Citations
About Us
Contact Us
Login to Protein Lounge!

Actin Nucleation and Branching

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

The actin family is a diverse and evolutionarily ancient group of proteins that provide the supportive framework to the three-dimensional structure of eukaryotic cells. It provides the forces that enable the cell to adopt a variety of shapes and to undertake directed movements. Certain cell types, such as polymorphonuclear leukocytes, monocyte/macrophages, and metastatic cells, are able to move rapidly through tissues and these movements are mediated by the actin cytoskeleton (Ref.1). An important property of actin is its ability to produce movement in the absence of motor proteins. At the cell membrane actin microfilament assembly protrudes the membrane forward producing the ruffling membranes in actively moving cells. These microfilaments also play a passive structural role by providing the internal stiffening [...]

References:

1.Actin nucleation: spire - actin nucleator in a class of its own.
Baum B, Kunda P.
Curr Biol. 2005 Apr 26;15(8):R305-8.
2.Actin binding proteins: regulation of cytoskeletal microfilaments.
dos Remedios CG, Chhabra D, Kekic M, Dedova IV, Tsubakihara M, Berry DA, Nosworthy NJ.
Physiol Rev. 2003 Apr; 83(2): 433-73. Review.
You can get all the details on this pathway through subscription