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Actin Nucleation by ARP-WASP Complex

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Actin Nucleation By ARP-WASP Complex For many cell types, the ability to move across a solid surface is fundamental to their biological function. Certain aspects of cell locomotion, such as the protrusion of the plasma membrane in lamellipodia and filopodia, are driven by the polymerization of actin cytoskeleton. The actin cytoskeleton is a dynamic filament network that is essential for cell movement during embryo development, polarization, morphogenesis, cell division, and immune system function and in the metastasis of cancer cells. To engage in these complex behaviors, cells must direct actin assembly with a high degree of spatial and temporal resolution in response to extracellular signals (Ref.1). To coordinate these behaviors, tight spatial and temporal control is exerted over several aspects [...]


1.Cortactin: a multifunctional regulator of cellular invasiveness.
Kirkbride KC, Sung BH, Sinha S, Weaver AM.
Cell Adh Migr. 2011 Mar-Apr;5(2):187-98. Epub 2011 Mar 1. Review.
2.Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes.
Burianek LE, Soderling SH.
Semin Cell Dev Biol. 2013 Apr;24(4):258-66. doi: 10.1016/j.semcdb.2012.12.005. Epub 2013 Jan 3. Review.
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