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Actin-Based Motility by Rho Family GTPases

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In response to a variety of extracellular stimuli, actin filament assembly at the leading edge of motile cells causes protrusion during cell crawling and chemotaxis, nerve growth and cell spreading. The actin filament network immediately under the plasma membrane in regions of rapid cellular protrusion consists of short, branched filaments while those deeper in the cortex, as well as at focal adhesions, stress fibers and in microvilli, are much longer and rarely branched (Ref.1). The dynamic organization of the actin cytoskeleton provides the force for cell motility and is regulated by small GTPases of the Rho family, in particular Rac1, RhoA and CDC42. The microtubule cytoskeleton is also polarized in a migrating cell, and in addition to organizing the actin [...]


1.Isotropic actomyosin dynamics promote organization of the apical cell cortex in epithelial cells.
Klingner C, Cherian AV, Fels J, Diesinger PM, Aufschnaiter R, Maghelli N, Keil T, Beck G, Tolić-Nørrelykke IM, Bathe M, Wedlich-Soldner R.
J Cell Biol. 2014 Oct 13;207(1):107-21. doi: 10.1083/jcb.201402037.
2.Rho GTPases at the crossroad of signaling networks in mammals.
Hervé JC, Bourmeyster N.
Small GTPases. 2015;6(2):43-8. doi: 10.1080/21541248.2015.1044811. Epub 2015 Jun 25. No abstract available.
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