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Actin-Based Motility by Rho Family GTPases

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Description

In response to a variety of extracellular stimuli, actin filament assembly at the leading edge of motile cells causes protrusion during cell crawling and chemotaxis, nerve growth and cell spreading. The actin filament network immediately under the plasma membrane in regions of rapid cellular protrusion consists of short, branched filaments while those deeper in the cortex, as well as at focal adhesions, stress fibers and in microvilli, are much longer and rarely branched (Ref.1). The dynamic organization of the actin cytoskeleton provides the force for cell motility and is regulated by small GTPases of the Rho family, in particular Rac1, RhoA and CDC42. The microtubule cytoskeleton is also polarized in a migrating cell, and in addition to organizing the actin cytoskeleton; Rho GTPases also [...]

References:

1.Actin nucleation: spire - actin nucleator in a class of its own.
Baum B, Kunda P.
Curr Biol. 2005 Apr 26;15(8):R305-8.
2.Cell motility: can Rho GTPases and microtubules point the way?
Wittmann T, Waterman-Storer CM.
J Cell Sci. 2001 Nov; 114(Pt 21): 3795-803. Review.
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