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Activation of NF-KappaB by PKR

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PKR (Protein Kinase-R) is a 68-kDa serine–threonine kinase that appears to play a primary role in mediating the antiviral activities of infected cells. PKR mediates apoptosis induced by many different stimuli, such as LPS (Lipopolysaccharides), TNF-Alpha (Tumour Necrosis Factor-Alpha), viral infection, or serum starvation. Viral infection leads to the increased expression and secretion of the cytokine IFN-Gamma (Interferon- Gamma) from host cells. IFN-gamma induces the dsRNA (Double-Stranded RNA)-dependent PKR. dsRNA, produced during viral replication, is an active component of a viral infection that stimulates antiviral responses in infected cells (Ref.1). The PKR protein is enzymatically inactive unless it is activated by binding to dsRNA. PKR activates as a kinase upon binding to dsRNA. Two DRBD (dsRNA Binding Domains) termed DRBDI [...]


1.Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heartfailure.
Wang H, Xu X, Fassett J, Kwak D, Liu X, Hu X, Falls TJ, Bell JC, Li H, Bitterman P, Bache RJ, Chen Y.
Circulation. 2014 Apr 1;129(13):1397-406. doi: 10.1161/CIRCULATIONAHA.113.002209. Epub 2014 Jan 24.
2.Stimulators of translation identified during a small molecule screening campaign.
Shin U, Williams DE, Kozakov D, Hall DR, Beglov D, Vajda S, Andersen RJ, Pelletier J.
Anal Biochem. 2014 Feb 15;447:6-14.
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