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Airway Inflammation in Asthma

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Asthma is a complex, chronic inflammatory lung disease that is characterized by epithelial shedding, airway smooth muscle hypertrophy and hyperplasia, overproduction of mucus, and airway inflammation. The pathophysiology of asthma has been attributed to an inflammatory process that occurs predominantly in the large airways (Ref.1) by the accumulation of eosinophils and CD4+ lymphocytes in the submucosa, mucous-gland hyperplasia, thickening of the sub epithelial collagen layer, submucosal matrix deposition, mast-cell degranulation, and hypertrophy and hyperplasia of the airway smooth muscle (Ref.2).

The epithelial cell is a focal point in the pathogenesis of viral respiratory infections because it serves as the host cell for viral replication, and it can also initiate innate immune responses. Chronic inflammation in asthma usually includes an increase in [...]


1.Airway immunopathology of asthma with exercise-induced bronchoconstriction.
Hallstrand TS, Moody MW, Aitken ML, Henderson WR Jr.
J Allergy Clin Immunol. 2005 Sep;116(3):586-93.
2.Mast-cell infiltration of airway smooth muscle in asthma.
Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID.
N Engl J Med. 2002 May 30; 346(22): 1699-705.
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