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Airway Pathology in COPD

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Description

Chronic obstructive pulmonary disease (COPD) is a major global health problem that is becoming preva¬lent, particularly in developing countries [Ref.1]. It is one of the most common diseases in the world, with a lifetime risk estimated to be as high as 25%, and now equally affects both men and women [Ref.2]. COPD is greatly under¬ diagnosed and often diagnosed late in its course, so there are vigorous attempts to increase awareness of this dis¬ease and to promote the use of spirometry to identify more patients [Ref.3]. COPD involves chronic inflammation of the periph-eral airways and lung parenchyma, which leads to pro¬gressive narrowing of the airways and shortness of breath [Ref.4.]

Cigarette smoke (and other irritants) activates macrophages and epithelial cells [...]

References:

1.Chronic obstructive pulmonary disease: a growing but neglected global epidemic.
Barnes PJ.
PLoS Med. 2007 May; 4(5):e112
2.Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study.
Gershon AS, Warner L, Cascagnette P, Victor JC, To T.
Lancet. 2011 Sep 10; 378(9795):991-6. doi: 10.1016/S0140-6736(11)60990-2.
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