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Signaling Pathways      Metabolic Pathways     All Pathways
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Vav Signaling in T-Lymphocyte
Vav (Oncogene Vav) family of proteins act as GEFs (Guanine Nucleotide Exchange Factors) and activators of Rho family GTPases, and are known to orchestrate cytoskeletal changes and cell migration in response to extracellular stimuli by catalyzing the exchange of GDP for GTP. Of the three mammalian isoforms, Vav1 is primarily expressed in hematopoietic cells, while Vav2 and Vav3 are
 
VEGF and S-1P Signaling
Angiogenesis is important in embryonic development as well as in physiological events and dysregulated angiogenesis is involved in various pathological conditions, like solid tumor growth, Rheumatoid Arthritis, and Diabetic Retinopathy. Angiogenesis is initiated by vascular endothelial cells and involves their orderly proliferation, migration, and morphogenesis into new capillary networks. Such [...]
 
VEGF Family Ligands and Receptor Interactions Recently Updated
VEGF (Vascular Endothelial Growth Factor) is a highly conserved genetic pathway that has evolved from simple to complex systems. The early evolutionary role of VEGF in simple invertebrate systems (Drosophila or fruit fly), was to guide the movement and dissemination of blood cells to eliminate dying cells and mount a defensive or [...]
 
VEGF Pathway
The formation of blood vessels occurs either by in situ differentiation of endothelial cell precursors (Angioblasts) and association of these cells to form primitive vessels, a process called Vasculogenesis, or by growth of preexisting vessels, a process called Angiogenesis. Vasculogenesis establishes the primary vascular plexus of the early embryo, whereas [...]
 
Virus-Induced Airway Inflammation
Virus-induced cytokine production and inflammatory cell activation are instrumental in the development of neurogenic inflammatory responses, and these combined factors increase bronchoconstriction in response to allergens or irritants. Viral infections can influence both the development and the severity of asthma. In early life, viral infections can either increase or, remarkably, [...]
 
Vitamin-C Transport
Vitamin-C (Ascorbate or Ascorbic Acid) is an essential water-soluble Vitamin, well known for its antiscorbutic and antioxidant functions in humans. Vitamin-C was first identified by virtue of the essential role it plays in Collagen modification, preventing the nutritional deficiency Scurvy. Vitamin-C acts as a cofactor for the P4H (Prolyl Hydroxylase) [...]
 
VPS34-PI3K Signaling in Saccharomyces cerevisiae
PI3Ks (Phosphoinositide-3 Kinases) are heterodimeric lipid kinases that are composed of a regulatory and catalytic subunit that are encoded by different genes (Ref.1). Two distinct VPS34P (Vacuolar Protein-Sorting-34-PI3K (Phosphatidylinositde-3 Kinase)) complexes occur in S. cerevisiae (Saccharomyces cerevisiae) in order to carry out autophagy and CpY (Carboxypeptidase-Y) sorting. VPS34P is activated [...]
 
West Nile Virus Replication
WNV (West Nile Virus) is a single-stranded positive-polarity RNA virus and the etiologic agent of West Nile encephalitis. It is a member of the Japanese encephalitis virus antigenic group within the family Flaviviridae, which can cause fatal encephalitis associated with damage to the CNS (Central Nervous System) in humans and [...]
 
WNT Signaling
The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross talk to provide positional information and induce cell fate specification. Together with other families of secreted factors such as TGF-Betas (Transforming Growth Factor-Betas), FGFs (Fibroblast Growth Factors), Hedgehog and Notch [...]
 
WNT Signaling in D. melanogaster
The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross talk to provide positional information and induce cell fate specification. Together with other families of secreted factors such as TGF-Betas (Transforming Growth Factor-Betas), FGFs (Fibroblast Growth Factors), Hedgehog and Notch [...]
 
Yersinia Infection
Yersinia pestis, a gram-negative bacillus, which is responsible for causing bubonic plague, is considered by the Center for Disease Control to be one of the top 5 bioterrorist agents. After infection, the pathogen invades lymphatic tissues and proliferates in the lymph nodes, and symptoms of pneumonic plague are expressed when [...]
 
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