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Allergic Response Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.


Atopy or Allergic disease is a complex familial disorder with multiple manifestations, including allergic asthma, rhinitis, conjunctivitis, and dermatitis. Allergens are derived from different sources such as cockroaches, ragweed pollens, and house dust mites. The primary immune cell lineages involved in the initiation and progression of allergic inflammation include DCs (Dendritic Cells), mast cells, basophils, eosinophils, and Th2 (Type-2 Helper T) cells. The responses of these principal players in allergic reactions are influenced by the local environments in which they reside. When susceptible or atopic individuals are initially exposed or sensitized to allergens, Antigen-presenting cells capture, process, and present allergen as an allergen-derived peptide fragment in the contest of specific MHC II (HLA II) molecules this induces allergen-specific acquired immune [...]


1.Regulation of allergic inflammation and eosinophil recruitment in mice lacking the transcription factor NFAT1: role of interleukin-4 (IL-4) and IL-5.
Viola JP, Kiani A, Bozza PT, Rao A.
Blood. 1998 Apr 1;91(7):2223-30.
2.The influence of TSLP on the allergic response.
Comeau MR, Ziegler SF.
Mucosal Immunol. 2010 Mar;3(2):138-47. doi: 10.1038/mi.2009.134.
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