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Alzheimer’s Disease Pathway

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Description

AD (Alzheimer’s Disease) is a neurodegenerative disorder leading to amnesia, cognitive impairment, and senile dementia. Two types of lesions characterize the disease: SPs (Amyloid or Senile Plaques) resulting from the extracellular aggregation of ABeta (Amyloid Beta) peptide, which is derived from a ubiquitous type I transmembrane protein named APP (Amyloid Precursor Protein), and NFTs (Neuro-Fibrillary Tangles) composed of intraneuronal bundles of PHF (Paired Helical Filaments). PHF result from the aggregation of pathologic Tau proteins, named PHF-Tau1. Both lesions extend progressively to neocortical brain areas during the course of Alzheimer Disease. The link between Amyloid deposits and NFTs is not yet clear. The vast majority of cases of Alzheimer Disease are sporadic with no clear pattern of inheritance and a late [...]

References:

1.The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.
Hamley IW.
Chem Rev. 2012 Oct 10;112(10):5147-92. doi: 10.1021/cr3000994. Epub 2012 Jul 19. Review. No abstract available.
2.Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
Cacquevel M, Aeschbach L, Houacine J, Fraering PC.
PLoS One. 2012;7(4):e35133. doi: 10.1371/journal.pone.0035133. Epub 2012 Apr 18.
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