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Androgen Signaling

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Description

Androgens are recognized as genotropic inducers of a number of physiological functions mainly associated with the development of sexual characteristics. Androgens promote the growth and differentiation of prostate cells through ligand activation of the AR (Androgen Receptor) (Ref.1&2). The AR, upon activation by Androgens, mediates transcription of target genes that modulate growth and differentiation of prostate epithelial cells. AR signaling is crucial for the development and maintenance of male reproductive organs including the prostate gland (Ref.3).

The majority of serum Androgens is complexed with the plasma glycoprotein SHBG (Sex Hormone-Binding Globulin). The plasma protein SHBG binds to a receptor SHBGR (Sex Hormone-Binding Globulin Receptor) on cell membranes to form an SHBG- SHBGR complex. SHBGR transduces its signal through G proteins. [...]

References:

1.Androgens are powerful non-genomic inducers of calcium sensitization in visceral smooth muscle.
González-Montelongo MC, Marín R, Gómez T, Díaz M.
Steroids. 2009 Oct 1.
2.Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.
Zhu ML, Kyprianou N.
Endocr Relat Cancer. 2008 Dec;15(4):841-9.
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