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Androgen Signaling

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Androgens are recognized as genotropic inducers of a number of physiological functions mainly associated with the development of sexual characteristics. Androgens promote the growth and differentiation of prostate cells through ligand activation of the AR (Androgen Receptor) (Ref.1&2). The AR, upon activation by Androgens, mediates transcription of target genes that modulate growth and differentiation of prostate epithelial cells. AR signaling is crucial for the development and maintenance of male reproductive organs including the prostate gland (Ref.3).

The majority of serum Androgens is complexed with the plasma glycoprotein SHBG (Sex Hormone-Binding Globulin). The plasma protein SHBG binds to a receptor SHBGR (Sex Hormone-Binding Globulin Receptor) on cell membranes to form an SHBG- SHBGR complex. SHBGR transduces its signal through G [...]


1.Androgens and androgen receptor signaling in prostate tumorigenesis.
Zhou Y, Bolton EC, Jones JO.
J Mol Endocrinol. 2015 Feb;54(1):R15-29. doi: 10.1530/JME-14-0203. Epub 2014 Oct 28. Review.
2.The differential role of androgens in early human sex development.
Hiort O.
BMC Med. 2013 Jun 24;11:152. doi: 10.1186/1741-7015-11-152. Review.
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