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Angiopoietin-TIE2 Signaling

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Development of a functional cardiovascular system is dependent on the regulated proliferation, migration, and differentiation of endothelial cells in two discrete processes known as vasculogenesis and angiogenesis. Angiogenesis is the formation of new capillaries from pre-existing vessels, whereas vasculogenesis is de-novo capillary formation from EPCs (Endothelial Precursor Cells). New capillaries arise from preexisting larger vessels to give rise to a more complex vascular network with a hierarchy of both large and small vessels (Ref.1). These sequential vascular developments are tightly regulated by a range of pro- and antiangiogenic factors, including VEGF (Vascular Endothelial Growth Factor ), bFGF(basic Fibroblast Growth Factor ), Thrombospondin, Angiopoietins, and more recently, Angptl (Angiopoietin-like proteins) (Ref.2).

The Angiopoietins are a new family of Growth Factor ligands that [...]


1.Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair.
Johnson KE, Wilgus TA.
Adv Wound Care (New Rochelle). 2014 Oct 1;3(10):647-661. Review.
2.miRNAs as modulators of angiogenesis.
Landskroner-Eiger S, Moneke I, Sessa WC.
Cold Spring Harb Perspect Med. 2013 Feb 1;3(2):a006643. doi: 10.1101/cshperspect.a006643. Review.
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