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Angiopoietin-TIE2 Signaling

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Description

Development of a functional cardiovascular system is dependent on the regulated proliferation, migration, and differentiation of endothelial cells in two discrete processes known as vasculogenesis and angiogenesis. Angiogenesis is the formation of new capillaries from pre-existing vessels, whereas vasculogenesis is de-novo capillary formation from EPCs (Endothelial Precursor Cells). New capillaries arise from preexisting larger vessels to give rise to a more complex vascular network with a hierarchy of both large and small vessels (Ref.1). These sequential vascular developments are tightly regulated by a range of pro- and antiangiogenic factors, including VEGF (Vascular Endothelial Growth Factor ), bFGF(basic Fibroblast Growth Factor ), Thrombospondin, Angiopoietins, and more recently, Angptl (Angiopoietin-like proteins) (Ref.2).

The Angiopoietins are a new family of Growth Factor ligands that [...]

References:

1.Angiogenesis and vasculogenesis in rheumatoid arthritis.
Szekanecz Z, Besenyei T, Szentpétery A, Koch AE.
Curr Opin Rheumatol. 2010 May;22(3):299-306. Review.
2.Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.
Yang YH, Wang Y, Lam KS, Yau MH, Cheng KK, Zhang J, Zhu W, Wu D, Xu A.
Arterioscler Thromb Vasc Biol. 2008 May;28(5):835-40. Epub 2008 Mar 13.
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