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Antimalaria Drug Mechanism

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The control of malaria largely depends on drug therapies, and, to a lesser extent, prophylaxis. Most of the antimalarial drugs available currently have been in use for decades, but their use is now severely limited by the emergence and spread of drug resistance, primarily in Plasmodium falciparum, the malaria parasite that causes severe forms of the disease and most of the disease burden. Drugs in use today target different stages of the malaria life cycle, albeit the majority of them act on the intra-erythrocytic phases of development of the malaria parasite (Ref. 1).

Some of the most widely used antimalarial drugs belong to the Folate antagonist class. These are basically nucleic acid inhibitors. Folate metabolism is the target of several [...]


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