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Antioxidant Action of Vitamin-C

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Oxidative stress/Hypoxia is induced by a wide range of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), oxygen shortage, etc. Generation of ROS (Reactive Oxygen Species) is characteristic feature of such stress conditions. Of the ROS, both Hydrogen Peroxide and Superoxide are produced in a number of cellular reactions and by various enzymes such as Lipoxygenases, Peroxidases, NADPH Oxidase, Xanthine Oxidase, etc to name a few. The main cellular components susceptible to damage by free radicals are lipids (peroxidation of unsaturated fatty acids in membranes), proteins (denaturation), carbohydrates and nucleic acids. Consequences of oxidative stress depend on tissue and/or species (i.e. their tolerance to Anoxia), on membrane properties, on endogenous antioxidant content and on the ability to induce the response in [...]


1.Antioxidants, oxidative damage and oxygen deprivation stress: a review.
Blokhina O, Virolainen E, Fagerstedt KV.
Ann. Bot (Lond). 2003 Jan;91 Spec No:179-94.
2.Vitamin C as an antioxidant: evaluation of its role in disease prevention.
Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M.
J. Am. Coll. Nutr. 2003 Feb;22(1):18-35.
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