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Apoptosis in Drosophila

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Apoptosis refers to an evolutionarily conserved method of Cell Death that is characterized by specific morphological and biochemical properties.  Morphologically, Apoptosis is characterized by a series of structural changes in dying cells: Blebbing of the plasma membrane, Condensation of the cytoplasm and nucleus, and Cellular Fragmentation into membrane Apoptotic bodies. Biochemically, Apoptosis is characterized by the degradation of Chromatin, initially into large fragments of 50-300 kilobases and subsequently into smaller fragments that are monomers and multimers of 200 bases. Programmed Cell Death by Apoptosis is a common way for deleting unwanted and superfluous cells. It is crucial during development as well as in the maintenance of tissue homeostasis and regulation of certain diseases (Ref.1). Apoptosis in Drosophila involves three death-inducing [...]


1.Programmed cell death in the embryonic central nervous system of Drosophila melanogaster.
Rogulja-Ortmann A, Luer K, Seibert J, Rickert C, Technau GM.
Development. 2007 Jan;134(1):105-16.
2.Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim.
Song Z, Guan B, Bergman A, Nicholson DW, Thornberry NA, Peterson EP, Steller H.
Mol Cell Biol. 2000 Apr;20(8):2907-14.
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