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Apoptotic Pathways in Synovial Fibroblasts

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RA (Rheumatoid Arthritis) is a chronic inflammatory disease of unknown etiology affecting diarthrodial joints. Inflammation and hyperplasia of the synovium are the hallmarks of RA. The normal synovium is a delicate tissue lining the joint capsule; however, in RA, the synovium transforms into an aggressive, tumor-like structure called the pannus. It is believed that inflammation promotes hyperplasia in the synovium, but the underlying mechanisms for this are largely unknown (Ref.1). Macrophages are major components in the inflammatory cascade and are also important mediators of joint destruction in RA. Large numbers of macrophages are present in synovial tissue and their cell numbers are associated with scores for local disease activity in clinically involved joints of RA patients (Ref.2).

Macrophage activity in the [...]


1.Macrophage migration inhibitory factor in rheumatoid arthritis.
Morand EF, Leech M.
Front Biosci. 2005 Jan 1;10:12-22.
2.Gene transfer of tissue inhibitor of metalloproteinases-3 reverses the inhibitory effects of TNF-alpha on Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
Drynda A, Quax PH, Neumann M, van der Laan WH, Pap G, Drynda S, Meinecke I, Kekow J, Neumann W, Huizinga TW, Naumann M, Konig W, Pap T.
J Immunol. 2005 May 15;174(10):6524-31.
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