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Assembly of RNA Polymerase-I Initiation Complex

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Description

The nuclei of all eukaryotic cells contain three different RNA Polymerases, designated I, II and III. Like the DNA Polymerase that catalyzes DNA replication, RNA Polymerases catalyze the formation of the phosphodiester bonds that link the nucleotides together to form a linear chain. The RNA Polymerase moves stepwise along the DNA, unwinding the DNA helix just ahead of the active site for polymerization to expose a new region of the template strand for complementary base-pairing. In this way, the growing RNA chain is extended by one nucleotide at a time in the 5’-to-3’ direction. The substrates are nucleoside triphosphates (ATP, CTP, UTP, and GTP); as for DNA replication, a hydrolysis of high-energy bonds provides the energy needed to drive the [...]

References:

1.RNA-polymerase-I-directed rDNA transcription, life and works.
Russell J, Zomerdijk JC.
Trends Biochem Sci. 2005 Feb; 30(2):87-96.
2.TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.
Friedrich JK, Panov KI, Cabart P, Russell J, Zomerdijk JC.
J Biol Chem. 2005 Aug 19; 280(33):29551-8. Epub 2005 Jun 21.
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