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Assembly of RNA Polymerase-II Initiation Complex

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Description

The nuclei of all eukaryotic cells contain three different RNA Polymerases, designated I, II and III. Like the DNA Polymerase that catalyzes DNA replication, RNA Polymerases catalyze the formation of the phosphodiester bonds that link the nucleotides together to form a linear chain. The RNA Polymerase moves stepwise along the DNA, unwinding the DNA helix just ahead of the active site for polymerization to expose a new region of the template strand for complementary base-pairing. In this way, the growing RNA chain is extended by one nucleotide at a time in the 5’-to-3’ direction. The substrates are nucleoside triphosphates (ATP, CTP, UTP, and GTP); as for DNA replication, a hydrolysis of high-energy bonds provides the energy needed to drive the [...]

References:

1.Crystal structure of yeast TATA-binding protein and model for interaction with DNA.
Chasman DI, Flaherty KM, Sharp PA, Kornberg RD.
Proc Natl Acad Sci U S A. 1993 Sep 1; 90(17):8174-8.
2.The role of enhancers as centres for general transcription factor recruitment.
Szutorisz H, Dillon N, Tora L.
Trends Biochem Sci. 2005 Nov; 30(11):593-9. Epub 2005 Aug 29.
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