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Assembly of RNA Polymerase-III Initiation Complex

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The nuclei of all eukaryotic cells contain three different RNA Polymerases, designated I, II and III. Like the DNA Polymerase that catalyzes DNA replication, RNA Polymerases catalyze the formation of the phosphodiester bonds that link the nucleotides together to form a linear chain. The RNA Polymerase moves stepwise along the DNA, unwinding the DNA helix just ahead of the active site for polymerization to expose a new region of the template strand for complementary base-pairing. In this way, the growing RNA chain is extended by one nucleotide at a time in the 5’-to-3’ direction. The substrates are nucleoside triphosphates (ATP, CTP, UTP, and GTP); as for DNA replication, a hydrolysis of high-energy bonds provides the energy needed to drive the [...]


1.Nhp6 is a transcriptional initiation fidelity factor for RNA polymerase III transcription in vitro and in vivo.
Kassavetis GA, Steiner DF.
J Biol Chem. 2006 Mar 17; 281(11):7445-51. Epub 2006 Jan 11.
2.Distinct transcriptional responses of RNA polymerases I, II and III to aptamers that bind TBP.
Fan X, Shi H, Lis JT.
Nucleic Acids Res. 2005 Feb 8; 33(3):838-45. Print 2005.
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