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Atherosclerosis-Disease Progression

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Atherosclerosis defines a disease in which the arterial wall becomes thickened and loses elasticity. It is a degenerative process in which fatty (lipid) material is deposited as Plaques irregularly and eccentrically in the walls of the Coronary Arteries and other Arteries as well. These Plaques are inflamed and encased in a thin fibrous capsule (connective tissue). As this lipid like material accumulates, it bulges into the opening of the Arteries, leading to varying degrees of obstruction of the blood flow to the heart muscle (Ref.1). As the obstruction increases there is less reserve for the heart to do work because of the reduction of blood and oxygen supply to the heart muscle. Ultimately there may be enough obstruction to cause [...]


1.Pathobiology of Atherosclerosis-a Brief Review.
Kher N, Marsh JD.
Semin Thromb Hemost. 2004 Dec;30(6):665-72.
2.[Atherosclerosis and arteriitis: implications for therapy of cardiovascular disease]
Galle J.
Herz. 2004 Feb;29(1):4-11. Review.
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