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Atherosclerosis-Disease Progression

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Atherosclerosis is a chronic disease, the prevalence of which has increased steadily as the population ages. Vascular injury is believed to be critical initiating event in pathogenesis of spontaneous atherosclerosis. Economic development and urbanization have promoted habits of diet rich in saturated fat and diminished physical activity, which favors atherosclerosis. Traditionally two types of atherosclerosis are described, spontaneous and accelerated. Accelerated atherosclerosis mainly occurs in patients after heart transplant, CABG (coronary artery bypass graft), and PTCA (percutaneous transluminal coronary angioplasty) [Ref.1]. The normal artery contains three layers. The inner layer, the tunica intima, is lined by a monolayer of endothelial cells that is in contact with blood overlying a basement membrane. It contains resident SMCs (smooth muscle cells). The middle [...]


1.Rapid Progression of Coronary Atherosclerosis: A Review.
Shah P, Bajaj S, Virk H, Bikkina M, Shamoon F.
Thrombosis. 2015; 2015:634983. doi: 10.1155/2015/634983. Epub 2015 Dec 28.
2.Progress and challenges in translating the biology of atherosclerosis.
Libby P, Ridker PM, Hansson GK.
Nature. 2011 May 19; 473(7347):317-25. doi: 10.1038/nature10146.
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