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Autoimmune Mechanism Causing Vitiligo

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Description

Vitiligo is an Acquired Skin Depigmenting disorder characterized by the loss of Melanocytes, Exocrine cells, from basal layer of the Epidermal and the matrix portion of the hair bulb. Vitiligo is defined clinically by expanding areas of well-circumscribed, milky white, cutaneous macules on the skin surface due to the destruction or inactivation of epidermal Melanocytes. It affects all races and occurs in 0.3–1.0% of the world population, and in 50% of cases the condition begins before the age of 20 years. More women than men are referred with Vitiligo, although the incidence of the disorder is not believed to be sex-linked. Vitiligo is not a physically debilitating disease; other than an increased sensitivity to UV radiation, most of the disease’s [...]

References:

1.Positive pleiotropic effects of HMG-CoA reductase inhibitor on Vitiligo.
Noel M, Gagne C, Bergeron J, Jobin J, Poirier P.
Lipids Health Dis. 2004 May 10;3(1):7.
2.Long-term follow-up study of segmental and focal Vitiligo treated by autologous, noncultured melanocyte-keratinocyte cell transplantation.
Mulekar SV.
Arch Dermatol. 2004 Oct;140(10):1211-5.
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