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B-Cell Development

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B lymphocytes are a population of white blood cells that express clonally diverse cell surface Ig (immunoglobulin) receptors, recognizing specific antigenic epitopes. The development of B-cells encompasses a continuum of stages that begin in primary lymphoid tissue (eg., human fetal liver and fetal/adult marrow), with subsequent functional maturation in secondary lymphoid tissue (eg., human lymph nodes and spleen). The functional/protective end point is antibody production by terminally differentiated plasma cells (Ref.1 ). B cells express immunoglobulin (Ig) molecules on their outer surface and secrete them into the extracellular space. Secreted Ig is known as antibody. Antibodies serve as effector molecules that neutralize microbes by binding to exposed antigens and targeting them to other components of the immune system, such as [...]


1.B lymphocytes: how they develop and function.
LeBien TW, Tedder TF.
Blood. 2008 Sep 1;112(5):1570-80.
2.SoDA2: a Hidden Markov Model approach for identification of immunoglobulin rearrangements.
Munshaw S, Kepler TB.
Bioinformatics. 2010 Apr 1;26(7):867-72.
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