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B-Cell Receptor Complex

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Description

Lymphocytes are one of the five kinds of white blood cells or leukocytes, circulating in the blood. Although mature lymphocytes all look pretty much alike, they are extraordinarily diverse in their functions. The most abundant lymphocytes are: B-Lymphocytes (often simply called B-Cells) and T-Lymphocytes (likewise called T-Cells) (Ref.1). B-Cells are not only produced in the bone marrow but also mature there. Each B-Cell is specific for a particular antigen. The specificity of binding resides in the BCR (B-Cell receptor) for antigen. They are integral membrane proteins. They are present in thousands of identical copies exposed at the cell surface. They are made before the cell ever encounters an antigen. B-Cell receptor complex usually consist of an antigen-binding subunit (the membrane [...]

References:

1.Regulation of adhesion and motility in B lymphocytes.
Severinson E, Westerberg L.
Scand J Immunol. 2003 Aug;58(2):139-44.
2.Role of the BCR Complex in B-Cell Development, Activation, and Leukemic Transformation.
Rheingold SR, Brown VI, Fang J, Kim JM, Grupp SA.
Immunol Res. 2003;27(2-3):309-30.
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