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BAFF in B-Cell Signaling

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Members of the TNF (Tumor Necrosis Factor) ligand family play important roles in various physiological and pathological processes, including cell proliferation, differentiation, apoptosis, modulation of immune response, and induction of inflammation. The BAFF (B-Cell Activating Factor) [also known as BLYS (B-Lymphocyte Stimulator), TALL1 (TNF- and ApoL-Related Leukocyte Expressed Ligand-1) or THANK (TNF Homolog that Activates Apoptosis, NF-KappaB, and JNK)] is a TNF-related ligand that promotes B-Cell survival. BAFF is expressed on dendritic cells, monocytes/macrophages, and T-Cells. BAFF is a positive regulator of B-Cell function, with effects on cell survival, activation, and differentiation (Ref.1).

BAFF is a homotrimer that is found as a membrane bound form in T-Cells and in a soluble form after cleavage by furin-type convertases that is released [...]


1.B cells, BAFF/zTNF4, TACI, and systemic lupus erythematosus.
Thomas Dörner and Chaim Putterman.
Arthritis Res. 2001; 3 (4): 197–199.
2.Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome.
Joanna Groom, Susan L. Kalled, Anne H. Cutler, Carl Olson, Stephen A. Woodcock, Pascal Schneider, Jurg Tschopp, Teresa G. Cachero,Marcel Batten,Julie Wheway, Davide Mauri, Dana Cavill, Tom P. Gordon, Charles R. Mackay,and Fabienne Mackay.
J Clin Invest. 2002 January 1; 109 (1): 59–68.
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