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BAFF in B-Cell Signaling

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Description

BAFF (B-cell activating factor), is a member of the TNF (tumor necrosis factor) ligand family that plays important roles in B-cell homeostasis, tolerance, and malignancy [Ref.1). It is also known as BLyS (B lymphocyte stimulator) protein, TALL-1 (TNF and apoptosis ligand-related leukocyte-expressed ligand-1), zTNF4, CD257, TNFSF13B, TNFS20 (TNF superfamily member) and THANK (TNF homolog that activates apoptosis, NF-B and c-Jun NH2-terminal kinase). It functions through three receptors i.e. TACI, BCMA and BAFFR (BAFF-receptor) (Ref.1).

Interaction of BAFF with BAFFR leads to recruitment of TRAF3 to the receptor and it is subsequently degraded by the combined actions of TRAF2 and cIAP1/2 (Ref.2). Lack of TRAF3 deactivates the TRAF/cIAP complex, releasing NIK and allowing it to accumulate in the cell. NIK then facilitates [...]

References:

1.Role of BAFF/BAFF-R axis in B-cell non-Hodgkin lymphoma.
Yang S, Li JY, Xu W.
Crit Rev Oncol Hematol. 2014 Aug;91(2):113-22. doi: 10.1016/j.critrevonc.2014.02.004. Epub 2014 Feb 23. Review.
2.Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures.
Gardam S, Brink R.
Front Immunol. 2014 Jan 6;4:509. doi: 10.3389/fimmu.2013.00509. eCollection 2014 Jan 6. Review.
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