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Description |
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Neurotrophins are required for the development and maintenance of the nervous system. The neurotrophin family consists of NGF (Nerve Growth Factor), BDNF (Brain Derived Neurotrophic Factor), NT3 (Neurotrophin-3), and NT4 (Neurotrophin-4). The functions of the neurotrophins are mediated by interacting with the TRK (Tyrosine Kinase) receptors: NGF with TRKA, BDNF and NT4 with TRKB, and NT3 with TRKC. Consequently, TRK receptor tyrosine kinases are activated, triggering multiple signaling pathways. The internalized TRK receptor remains tyrosine phosphorylated and activated, with its extracellular domain bound to the ligand neurotrophin inside the signaling endosomes, and the intracellular domain tightly associated with a number of signaling molecules such as PLC-Gamma (Phospholipase-C), PI3K (Phosphatidylinositol 3-Kinase), and proteins of the Ras–MAPK (Mitogen-Activated Protein Kinase) pathway in [...] |
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