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BMP Pathway

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The fate of neural precursors in the developing brain is believed to be determined by intrinsic cellular programs and by external cues, including the cytokines. BMPs (Bone Morphogenetic Proteins) are a large subclass (more than 20 members) of the TGF-Beta (Transforming Growth Factor-Beta) super family that is active in many tissues under normal physiologic conditions, and are regulated through reversible interactions with extracellular antagonists, including noggin, chordin, follistatin, and Gremlin. These interactions determine the bioavailability of different BMPs for binding to their cognate receptors and activation of down-stream responses. BMPs themselves are further classified into several subgroups on the basis of sequence similarities and homology. These include BMP2, BMP4, decapentaplegic BMP5, BMP6, BMP7 and BMP8 (Ref.1& 2). Although originally named [...]


1.Bone morphogenetic protein receptors and signal transduction.
Miyazono K, Kamiya Y, Morikawa M.
J Biochem. 2010 Jan;147(1):35-51.
2.Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts).
Bessa PC, Casal M, Reis RL.
J Tissue Eng Regen Med. 2008 Jan;2(1):1-13.
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