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BMP Pathway

This image is a scaled-down version of the actual pathway image. It does not contain any links to the protein information pages.
 

Description

BMPs (Bone morphogenetic proteins) are the members of the transforming growth factor-beta superfamily of secreted signaling molecules [Ref.1]. Transduction of BMP signal involves two types of transmembrane serine/threonine kinase receptors: type I and type II [Ref.1]. BMP2, BMP4, BMP5,BMP6, BMP7, BMP8, BMP9, BMP10, BMP12, BMP13 and BMP14 (Bone morphogenetic protein 2, 4, 5, 6 ,7, 8, 9, 10, 12, 13 and 14) can bind to three type I receptors: BMPR1A (Bone morphogenetic protein receptor, type IA), BMPR1B (Bone morphogenetic protein receptor, type IB) and ALK-2 (Activin A receptor, type I) and two type II receptor, BMPR2A (Bone morphogenetic protein receptor type IIA) and ACTRIIA [Ref.1]. Various antagonists such as, Noggin, Tsg (twisted gastrulation), GREM1, Follistatin and Chordin bind to [...]

References:

1.TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation.
Rahman MS, Akhtar N, Jamil HM, Banik RS, Asaduzzaman SM.
Bone Res. 2015 Apr 14; 3:15005. doi: 10.1038/boneres.2015.5. eCollection 2015. Review.
2.BMP signaling in vascular diseases.
Cai J, Pardali E, Sánchez-Duffhues G, ten Dijke P.
FEBS Lett. 2012 Jul 4; 586(14):1993-2002. doi: 10.1016/j.febslet.2012.04.030. Epub 2012 May 3. Review.
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