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Base Excision Repair Pathway

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Description

The survival of organism depends on the accurate transmission of genetic information from one cell to its daughters. Such faithful transmission requires not only extreme accuracy in replication of DNA and precision in chromosome distribution, but also the ability to survive spontaneous and induced DNA damage while minimizing the number of heritable mutations. To achieve this fidelity, cells have evolved surveillance mechanisms that monitor the structure of chromosomes and coordinate repair and cell cycle progression. BER (Base Excision Repair) is the main guardian against the most frequent types of DNA damage due to cellular metabolism, including that resulting from ROS (Reactive Oxygen Species), methylation, deamination, hydroxylation or spontaneous loss of the DNA base itself (Ref.2). These alterations, although simple in [...]

References:

1.The DNA damage response: putting checkpoints in perspective.
Zhou BB, Elledge SJ.
Nature. 2000 Nov 23; 408(6811): 433-9. Review.
2.Genome maintenance mechanisms for preventing cancer.
Hoeijmakers JH.
Nature. 2001 May 17; 411(6835): 366-74. Review.
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