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Beta-Adrenergic Signaling

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Description

The rate and strength of beating of the heart is under the reciprocal control of the Adrenergic (sympathetic) and Cholinergic (parasympathetic) systems. Increased strength (inotropy) in cardiac beating in response to hormones like the blood-borne Epinephrine or to neurally delivered Norepinephrine is mediated by ADR-Beta (Beta-Adrenergic Receptors) , which are members of the superfamily of cell surface receptors that carry out signaling via coupling to G-proteins (Guanine nucleotide binding proteins)(Ref.1). ADR forms the interface between the endogenous Catecholamines, Adrenaline, Epinephrine and Norepinephrine and a wide array of target cells in the body to mediate the biological effects of the Sympathetic Nervous System. They serve critical roles in maintaining homeostasis in normal physiologic settings as well as pathologic states. The family [...]

References:

1.Autonomic and endocrine control of cardiovascular function.
Gordan R, Gwathmey JK, Xie LH.
World J Cardiol. 2015 Apr 26;7(4):204-14. doi: 10.4330/wjc.v7.i4.204. Review.
2.Adrenergic regulation of innate immunity: a review.
Scanzano A, Cosentino M.
Front Pharmacol. 2015 Aug 13;6:171. doi: 10.3389/fphar.2015.00171. eCollection 2015. Review.
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