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Beta-Adrenergic Signaling

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The rate and strength of beating of the heart is under the reciprocal control of the Adrenergic (sympathetic) and Cholinergic (parasympathetic) systems. Increased strength (inotropy) in cardiac beating in response to hormones like the blood-borne Epinephrine or to neurally delivered Norepinephrine is mediated by ADR-Beta (Beta-Adrenergic Receptors) (Ref.1), which are members of the superfamily of cell surface receptors that carry out signaling via coupling to G-proteins (Guanine nucleotide binding proteins). ADR forms the interface between the endogenous Catecholamines, Adrenaline, Epinephrine and Norepinephrine and a wide array of target cells in the body to mediate the biological effects of the Sympathetic Nervous System. They serve critical roles in maintaining homeostasis in normal physiologic settings as well as pathologic states. The family of human ADRs consists [...]


1.Mechanisms of disease: beta-adrenergic receptors--alterations in signal transduction and pharmacogenomics in heart failure.
Feldman DS, Carnes CA, Abraham WT, Bristow MR.
Nat Clin Pract Cardiovasc Med. 2005 Sep; 2(9):475-83.
2.Alterations in adrenergic receptor signaling in heart failure.
Lamba S, Abraham WT.
Heart Fail Rev. 2000 Mar; 5(1):7-16.
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