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Biosynthesis of Arginine in Bacteria

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In bacteria, biosynthesis of arginine proceeds from glutamate in eight enzymatic steps initiated by the acetylation of glutamate by N-Acetyl Glutamate Synthetase. The N-Acetylated intermediates lead to ornithine. The synthesis of ornithine, like that of proline, involves the activation and reduction of the 5-carboxyl group of glutamate. In prokaryotes the pathway of arginine biosynthesis follows two alternative patterns which differ by the strategies used for the removal of the acetyl group and for the control of the metabolite flow along the pathway. Enterobacteriaceae and Bacillaceae use a linear pathway in which the formation of ornithine from N-Acetylornithine is mediated by the hydrolytic enzyme N-acetylornithinase (Ref.1). In these organisms, acetyl glutamate synthetase, the first enzyme of the pathway, is the target [...]


1.Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria.
Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M.
J Biol Chem. 2005 Apr 15;280(15):14366-9. Epub 2005 Feb 24.
2.The nucleotide sequence of the yeast ARG4 gene.
Beacham IR, Schweitzer BW, Warrick HM, Carbon J.
Gene. 1984 Sep; 29(3):271-9.
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