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Biosynthesis of Lysine

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The amino acid L-lysine is synthesized by plants and microorganisms by two different pathways, one proceeding via Diaminopimelate and the other via Alpha-Aminoadipate. Humans, however, cannot synthesise the compound and so it is an essential part of their diet. The Diaminopimelate pathway operates in bacteria, lower fungi and green plants. This pathway is the source of the lysine and Diaminopimelate incorporated into bacterial cell wall peptidoglycan and therefore there has been extensive investigation of its enzymes with a view to the development of new antibacterial agents. In Euglenoids and higher fungi lysine biosynthesis occurs via the Homocitrate-Aminoadipate pathway. An intermediate on this pathway (Alpha-Aminoadipic acid) is necessary for Beta-lactam antibiotic biosynthesis (Ref.1).

The Diaminopimelate route begins with the phosphorylation of [...]


1.Molecular evolution of the lysine biosynthetic pathways.
Velasco AM, Leguina JI, Lazcano A.
J Mol Evol. 2002 Oct;55(4):445-59.
2.Distribution of genes for lysine biosynthesis through the aminoadipate pathway among prokaryotic genomes.
Nishida H.
Bioinformatics. 2001 Feb;17(2):189-91.
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