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Biosynthesis of Threonine and Methionine

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Threonine is an alcohol-containing amino acid that can not be produced by metabolism and must be taken in the diet. This amino acid plays an important role along with Glycine and Serine in Porphyrin metabolism. Threonine is incorporated into proteins and enzymes at a molar rate of 6 percent compared to the other amino acids. Methionine is the only sulfur-containing amino acid that is essential for mammals and must therefore be derived entirely from the diet (Ref.1). Methionine is an important amino acid that helps to initiate translation of mRNA (messenger RNA) by being the first amino acid incorporated into the N-terminal position of all proteins. This sulfur-containing amino acid is also the source of sulfur for Cysteine in animals [...]


1.The specific features of methionine biosynthesis and metabolism in plants.
Ravanel S, Gakière B, Job D, Douce R.:
Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13): 7805-7812
2.Approaches towards understanding methionine biosynthesis in higher plants.
Hesse H, Kreft O, Maimann S, Zeh M, Willmitzer L, Hofgen R.
Amino Acids. 2001;20(3):281-9.
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