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Biotin Biosynthesis in B. sphaericus

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Biotin (Vitamin-H) is essential for all living organisms and acts as a cofactor for a few essential enzymes of the Carboxylase family. Higher plants, most fungi and bacteria, are prototrophic for Biotin. Others, including most vertebrates and some bacteria, rely on exogenous sources. In mammals, Biotin is supplied by intestinal bacteria. Biotin is a colorless Vitamin and Orthorhombic when crystallized. It consists of two fused rings: an Imidazol (Ureido) and a Sulfur-containing (Tetrahydrothiophene) ring; and the latter is extended via a Valeric acid side chain, which is attached in a cis-configuration with respect to the Ureido ring. Both rings are fused in cis. Biotin contains three chiral carbon atoms, resulting in eight possible Stereoisomers (Ref.1). The Biotin only possesses Vitamin [...]


1.Biotinidase deficiency: novel mutations and their biochemical and clinical correlates.
Wolf B, Jensen KP, Barshop B, Blitzer M, Carlson M, Goudie DR, Gokcay GH, Demirkol M, Baykal T, Demir F, Quary S, Shih LY, Pedro HF, Chen TH, Slonim AE.
Hum. Mutat. 2005 Apr;25(4):413.
2.Biotin in microbes, the genes involved in its biosynthesis, its biochemical role and perspectives for biotechnological production.
Streit WR, Entcheva P.
Appl. Microbiol. Biotechnol. 2003 Mar;61(1):21-31.
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