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Biotin Metabolism

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Biotin is a water-soluble Vitamin required by all organisms by virtue of its essential role in carboxylation reactions. Whereas animals lack the ability to synthesize Biotin, it is synthesized by microorganisms and plants and therefore is widespread in the food supply at low concentrations relative to most water-soluble Vitamins (Ref.1). The highest level of Biotin occurs in organ meats such as liver and kidney, but it is low in meats, most vegetables, and fruits. It is also known as Vitamin-H. This member of Vitamin B-Complex group is colorless, withstands high temperatures and is orthorhombic when crystallized. It consists of two fused rings: an Imidazol (Ureido) and a Sulfur-containing (Tetrahydrothiophene) ring; and the latter is extended via a Valeric acid side [...]


1.Biotin in metabolism and molecular biology.
McMahon RJ.
Annu. Rev. Nutr. 2002;22:221-39.
2.Molecular genetics of biotin metabolism: old vitamin, new science.
Gravel RA, Narang MA.
J. Nutr. Biochem. 2005 Jul;16(7):428-31.
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