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Biotin Metabolism in B. subtilis

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The colorless and orthorhombic Vitamin, Biotin or Vitamin-H, is essential for all living organisms and acts as a cofactor for a few essential enzymes of the Carboxylase family. Bacteria, most fungi and higher plants, are prototrophic for Biotin. Most vertebrates and even some bacteria, rely on exogenous sources. In mammals, Biotin is supplied by intestinal bacteria. In general, Biotin consists of two fused rings: an Imidazol (Ureido) and a Sulfur-containing (Tetrahydrothiophene) ring; and the latter being extended via a Valeric acid side chain, which is attached in a cis-configuration with respect to the Ureido ring. Both rings are fused in cis. Biotin contains three [...]


1.Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction.
Van Arsdell SW, Perkins JB, Yocum RR, Luan L, Howitt CL, Prasad Chatterjee N, Pero JG.
Biotechnol. Bioeng. 2005 May 2.
2.Expression, purification and characterization of cytochrome P450 Biol: a novel P450 involved in biotin synthesis in Bacillus subtilis.
Green AJ, Rivers SL, Cheeseman M, Reid GA, Quaroni LG, Macdonald ID, Chapman SK, Munro AW.
J. Biol. Inorg. Chem. 2001 Jun;6(5-6):523-33.
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