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Biotin Metabolism in E. coli K-12

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One of the most fascinating cofactors involved in central pathways of pro- and eukaryotic cell metabolism belongs to the B-Complex group of Vitamins known as Biotin or Vitamin-H. Biotin is a colorless and orthorhombic, consisting of two fused rings: an Imidazol (Ureido) and a Sulfur-containing (Tetrahydrothiophene) ring; and the latter is extended via a Valeric acid side chain, which is attached in a cis-configuration with respect to the Ureido ring. Both rings are fused in cis. Biotin contains three chiral carbon atoms, resulting in eight possible Stereoisomers. However, only the Biotin possesses Vitamin activity. The correct chemical name for the cofactor is: Hexahydro-2-Oxo-1H-Thieno (3,4-D) Imidazole-4-Pentanoic Acid. It is noteworthy that this Vitamin [...]


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