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Biotin Metabolism in H. sapiens

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Biotin or Vitamin-H, an essential micronutrient for all mammals belongs to the B-Complex group of Vitamins. It is a water-soluble Vitamin used as co-factor of Biotin-dependent Carboxylases. The role of Biotin in Carboxylases is to act as vector for carboxyl-group transfer between donor and acceptor molecules during Carboxylation reaction (Ref.1). In H. sapiens (Homo sapiens), Biotin is a covalently bound as a prosthetic group for five Biotin-dependent Carboxylases namely PCC (Propionyl-CoA Carboxylase) group; PC (Pyruvate Carboxylase, Mitochondrial); MCC (Methylcrotonyl-Coenzyme-A Carboxylase) group; ACAC-Alpha (Acetyl-Coenzyme-A Carboxylase-Alpha) and ACAC-Beta (Acetyl-Coenzyme-A Carboxylase-Beta). Biotin is covalently attached to Carboxylases by the enzyme HLCS (Holocarboxylase Synthetase (Biotin-(Proprionyl-Coenzyme-A [...]


1.A human biotin acceptor domain allows site-specific conjugation of an enzyme to an antibody-avidin fusion protein for targeted drug delivery.
Asai T, Trinh R, Ng PP, Penichet ML, Wims LA, Morrison SL.
Biomol. Eng. 2005 Feb;21(6):145-55.
2.Biotin in metabolism and its relationship to human disease.
Pacheco-Alvarez D, Solorzano-Vargas RS, Del Rio AL.
Arch. Med. Res. 2002 Sep-Oct;33(5):439-47.
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