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Biotin Metabolism in M. loti

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Symbiotic bacteria, together with Phytopathogenic microbes, are plant-interacting microorganisms of major agronomic importance. Among these, Rhizobia are root-nodule-forming Nitrogen-Fixing Legume Symbionts. These microorganisms, in addition to providing an ideal model for studying plant-microbe interactions, play an important role in global nutrient cycling. In Rhizobium sp. also known as Mesorhizobium sp., the majority of the symbiosis genes are contained on a 500 kb (500 Kilobase) chromosomal genetic element termed a Symbiosis Island (Strain R7A). Phenotypic characterization of the Non-Symbionts present in the environment, reveals that they are initially auxotrophic for Biotin (or Vitamin-H) and Thiamin (Vitamin-B1) (Ref.1). Transfer of the Symbiosis Island [...]


1.Biotin biosynthesis, transport and utilization in rhizobia.
Guillen-Navarro K, Encarnacion S, Dunn MF.
FEMS Microbiol. Lett. 2005 May 15;246(2):159-65.
2.Expression islands clustered on the symbiosis island of the Mesorhizobium loti genome.
Uchiumi T, Ohwada T, Itakura M, Mitsui H, Nukui N, Dawadi P, Kaneko T, Tabata S, Yokoyama T, Tejima K, Saeki K, Omori H, Hayashi M, Maekawa T, Sriprang R, Murooka Y, Tajima S, Simomura K, Nomura M, Suzuki A, Shimoda Y, Sioya K, Abe M, Minamisawa K.
J. Bacteriol. 2004 Apr;186(8):2439-48.
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