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Bitter Taste Signaling

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The sense of taste plays a critical role in the life and nutritional status of humans and other organisms. Human taste perception may be categorized according to four well known and widely accepted descriptors, sweet, bitter, salty, and sour (corresponding to particular taste qualities or modalities), and two more controversial qualities: fat and amino acid taste. In addition to these basic tastes, the taste buds also detect a meat-like taste known as umami in protein-rich food. The food chemicals that produce tastes set off different reactions from the taste buds with a main goal of sending signals along nerve fibers to the brain for interpretation. The perception of bitter taste is essential for its protective value, enabling humans to avoid [...]


1.Molecular mechanisms of bitter and sweet taste transduction.
Margolskee RF.
J Biol Chem. 2002 Jan 4; 277(1):1-4. Epub 2001 Nov 05.
2.Elucidation of mammalian bitter taste.
Meyerhof W.
Rev Physiol Biochem Pharmacol. 2005 Jul 20
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