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Blood Coagulation Cascade

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The circulatory system must be self-sealing; otherwise continued blood loss from even the smallest injury would be life threatening. Normally, all but the most catastrophic bleeding is rapidly stopped, by a process known as Coagulation, through several sequential processes. Coagulation involves the formation of a blood clot (thrombus) that prevents further blood loss from damaged tissues, blood vessels or organs. This is a complicated process with a cellular system comprised of cells called platelets that circulate in the blood and serve to form a platelet plug over damaged vessels and a second system based upon the actions of multiple proteins (called clotting factors) that act in concert to produce a fibrin clot. These two systems work in concert to form [...]


1.A cell-based model of thrombin generation.
Roberts HR, Hoffman M, Monroe DM.
Semin Thromb Hemost. 2006 Apr;32 Suppl 1:32-8.
2.Rethinking the coagulation cascade.
Hoffman MM, Monroe DM.
Curr Hematol Rep. 2005 Sep;4(5):391-6.
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