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Breast Cancer Regulation by Stathmin1

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Description

Stmn1 (Stathmin-1) also referred to as Op18 (Oncoprotein-18) is a major regulator of microtubule dynamics. It is an evolutionarily well conserved 17 kDa cytoplasmic phosphoprotein that is highly expressed in a wide variety of cancers and its high abundance seems to be necessary for the maintenance of the transformed phenotypes. Breast cancers exhibit high levels of Stmn1 and may be resistant to anti-microtubule agents. Stmn1 destabilizes microtubule polymers of Alpha and Beta-Tubulin subunits, by promoting catastrophes that ultimately results in deregulation of cell cycle, hampering cell survival (Ref.1). One of the key properties of microtubules is that of ‘dynamic instability’. Dynamic instability comprises the continuous switching between catastrophes (depolymerization or shrinkage phase) and rescues (polymerization or growing phase) of individual microtubules. Stmn1 expression is ubiquitous and [...]

References:

1.The oncoprotein 18/stathmin family of microtubule destabilizers.
Cassimeris L.
Curr. Opin. Cell Biol. 2002 Feb;14(1):18-24.
2.The effect of stathmin phosphorylation on microtubule assembly depends on tubulin critical concentration.
Amayed P, Pantaloni D, Carlier MF.
J. Biol. Chem. 2002 Jun 21;277(25):22718-24.
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